Tress MacNeille is an American voice actress best known for providing various voices on the animated series The Simpsons, Futurama, Tiny Toon Adventures, Disney's House of Mouse, Courage the Cowardly Dog, and more.
MacNeille was born in California. She loved cartoons as a child and wanted to be a voice actress from the age of eight, but opted instead for a "practical" career, feeling she would never be able to realize her ambition. She graduated from the University of California, Berkeley and attended broadcasting school, becoming a disc jockey.
MacNeille worked in a variety of jobs and had numerous minor voice-over roles before becoming a regular on an animated TV show. She had "been doing radio spots, some TV, demos, sound-alikes, industrial narrations — anything that came my way for about two years." She was also a member of the improvisational comedy group The Groundlings for ten years. MacNeille took acting workshops and worked as a casting assistant for voice acting talent agent Bob Lloyd in what she calls "The University of Voice-over". Lloyd and fellow agent Rita Vennari got MacNeille her first role on an animated show with a part in a 1979 episode of Scooby-Doo and Scrappy-Doo.