John DiMaggio attended the Mason Gross School of the Arts, Rutgers University, for two years. He was a member of the Gamma Sigma fraternity.
He is also a highly skilled beatboxer, as can be heard in the Futurama episode Luck of the Fryrish as the character Noticeably F.A.T. and recorded an a cappella version of the theme for two episodes with Billy West. He also beatboxed with Coolio, as Kwanzaabot, on Bender's Big Score.
He is best known for his voice roles of Bender in Futurama, Dr. Drakken and Motor Ed in Kim Possible, Marcus Fenix in the Gears of War series, Rico in The Penguins of Madagascar, and Wakka as well as Kimahri Ronso in Final Fantasy X, Schnitzel in the animated child comedy Chowder, Jake the dog in the new animated series Adventure Time with Finn and Jake, Bobo Haha and Skalamander on Generator Rex, both currently airing on Cartoon Network, and The Joker in the eighth installment of the DC Universe Animated Original Movies series Batman: Under the Red Hood. He also currently voices the Niblet the Sheepdog in Pound Puppies which premiered October 10, 2010 on The Hub.