A native of Big Bear Lake, California, when not working, Jillian attends public school, where she is a straight A student and in the GATE program, and plays softball on a local team. She is the younger sister of actors Aaron Henry and Michael Tyler Henry.
Jillian is often cast as the "smart girl". She has guest starred on My Wife and Kids, What I Like About You, Six Feet Under, and Carnivàle. More recently, she starred with Rob Schnieder, David Spade, and Jon Heder as technology geek Gretchen in the feature film, The Benchwarmers.