Taylor is a long-time comic book and Star Wars fan, and is married to Allison Taylor. Together they have one daughter who is described as "[talking] about Obi-Wan all the time".
At Star Wars Weekends in 2010, he and Star Wars: The Clone Wars co-star Ashley Eckstein were demonstrating to fans how they perform voice-acting for the show. While doing this, James invited his daughter to the stage where she lent her voice to Fred Tatasciore's character of The Zillo Beast from The Clone Wars episodes: The Zillo Beast and The Zilo Beast Strikes Back.
He is good friends with voice actors David Kaye, Jim Ward, Corey Burton, Tom Kane, Diedrich Bader, Tom Kenny, Kath Soucie, Jess Harnell, Dee Bradley Baker, Neil Flynn, Ben Diskin, John DiMaggio, Tara Strong, Kevin Michael Richardson, Chris Edgerly and Leslie Carrara-Rudolph along with others. He and Burton performed their own version of How the Grinch Stole Christmas using the voices of Obi-Wan Kenobi, Cad Bane, and Ziro The Hutt. The video has been posted on YouTube.
He provides the English voice work in Square Enix's popular video game, Final Fantasy X, as the voice of Tidus. He is also known as the voice of Ratchet in the popular Ratchet & Clank video game series from Insomniac Games, except for the original game, wherein Ratchet was voiced by Mikey Kelley; as well as Leonardo from TMNT. Taylor's other large roles include the role of Wooldoor Sockbat on the Comedy Central animated series Drawn Together, voice acting for Captain Jack Sparrow in Kingdom Hearts II, and providing the voices for many characters in The Animatrix. He reprises his role as Tidus in the action/fighting game Dissidia: Final Fantasy and is set to do so again in the game's prequel Dissidia 012 Final Fantasy. He also starred in the 2004 mockumentary Comic Book: The Movie, his only live action role to date. He played the role of the Agori, Berix and the Glatorian, Vastus in the recent direct-to-DVD film, BIONICLE: The Legend Reborn. He has also voiced Electro in the Ultimate Spider Man video game from 2005.