"Grey DeLisle, the actress who plays Azula, is just unbelievable. She was able to bring a really amazing realism to Azula, without being kind of a cackling villain."
— Michael Dante DiMartino in "The Women of Avatar: The Last Airbender".
Grey DeLisle had a difficult childhood; her mother was addicted to drugs, and she was primarily raised by her grandmother, Eva Flores Ruth, a vocalist who performed with salsa legend Tito Puente.
DeLisle was heavily into goth bands like The Cure, but her mother, who had become a born-again Pentecostal, set a strict rule forbidding secular music. In her late teens, she started singing old gospel tunes and entered the world of stand-up comedy on the advice of a close friend. In her comedy routine, DeLisle imitated voices particularly well and was advised to take a shot at voice acting. Her first starring role came in the first English version of Crayon Shin-Chan, as the voice of characters Cosmo and Uma, in 1994.
In 2002, DeLisle married musician Murry Hammond, the bassist for the Old 97's, after a few months in a long-distance relationship. They were featured in an episode of The Learning Channel program A Wedding Story. Their first child, Jefferson Texas "Tex" Hammond, was born on January 31, 2007 in Los Angeles, California.
Billed as a "Superstar Voice Actress" on the Anime News Network, DeLisle has played the leading role in many animated series. Harp Magazine has called Delisle "golden-voiced" and recognized her for her roles in Fairly Oddparents, What's New, Scooby-Doo?, and Clifford the Big Red Dog. In addition to her numerous English-speaking roles, she also speaks Japanese as the character Yumi on Hi Hi Puffy AmiYumi. DeLisle has had voice acting roles in many computer and video games, such as Escape from Monkey Island, Baldur's Gate 2, Tomb Raider: Anniversary, and several Star Wars games. She also voices the Dark Jedi, Asajj Ventress, in Star Wars: Clone Wars, Therese and Jeanette (Tourette) Voerman in the White Wolf RPG, PC game Vampire The Masquerade: Bloodlines, Samantha Manson in Danny Phantom, Frankie in Foster's Home for Imaginary Friends, and Frida Suárez in El Tigre: The Adventures of Manny Rivera. DeLisle has released four music CDs, which include goth-inspired folk and Americana tunes, and a few gospel-style songs.
Grey occasionally refers to her former co-star Dante Basco as her brother, as the two portrayed brother and sister in Avatar: The Last Airbender.
DeLisle once stated in an interview that Azula is her favorite character of all those she has voiced.
In the TV series XiaolinShowdown, DeLisle voices main character Kimiko Tohomiko, a Japanese girl who stays at a Chinese temple (along with the rest of the main characters) and is the "Dragon Of Fire".
Xiaolin Showdown bears many similarities to Avatar: The Last Airbender, primarily in that the main character is a small, bald boy who grew up in a temple and is not in his comfort zone away from the monks who raised him.